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| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Marcos Giron | Win | 6-3, 5-7, 6-3 |
| Second Round | Mackenzie McDonald | Win | 7-6 (9-7), 6-1 |
| Quarterfinals | Hubert Hurkacz | Loss | 6-7 (2-7), 6-7 (4-7) |
| Libema Open | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tallon Griekspoor | Win | 7-6 (7-2), 7-6 (7-5) |
| Quarterfinals | Karen Khachanov | Win | 7-6 (7-5), 6-4 |
| Semifinals | Tim Van Rijthoven | Loss | 3-6, 6-1, 6-7 (5-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Juan Pablo Varillas | Win | 2-6, 2-6, 6-1, 6-3, 6-3 |
| Second Round | Camilo Ugo Carabelli | Win | 6-0, 6-3, 6-4 |
| Third Round | Filip Krajinovic | Win | 7-6 (7-3), 7-6 (7-2), 7-5 |
| Fourth Round | Rafael Nadal | Loss | 6-3, 3-6, 2-6, 6-3, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Davidovich Fokina | Win | 4-6, 7-6 (7-2), 6-2 |
| Third Round | Marcos Giron | Win | 6-3, 6-2 |
| Quarterfinals | Novak Djokovic | Loss | 5-7, 6-7 (1-7) |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cristian Garin | Win | 6-3, 6-0 |
| Third Round | Jannik Sinner | Win | 6-1, 6-2 |
| Quarterfinals | Alexander Zverev | Loss | 3-6, 5-7 |
| Millennium Estoril Open | ||
| Surface: Red Clay | Date: Apr. 25 - May 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carlos Taberner | Win | 1-6, 6-2, 6-2 |
| Quarterfinals | Sebastian Korda | Loss | 2-6, 2-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carlos Taberner | Win | 6-1, 3-6, 6-4 |
| Third Round | Frances Tiafoe | Win | 7-5, 6-4 |
| Quarterfinals | Diego Schwartzman | Loss | 6-3, 2-6, 3-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lorenzo Musetti | Loss | 2-6, 6-7 (2-7) |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 4 - Apr. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Elliot Benchetrit | Win | 6-3, 6-3 |
| Second Round | Alex Molcan | Loss | 4-6, 6-2, 6-7 (7-9) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Miomir Kecmanovic | Loss | 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Botic van de Zandschulp | Loss | 6-7 (4-7), 7-6 (7-4), 3-6 |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 14 - Feb. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jo-Wilfried Tsonga | Win | 7-6 (7-3), 6-2 |
| Quarterfinals | Ilya Ivashka | Win | 6-3, 6-4 |
| Semifinals | Roman Safiullin | Win | 7-6 (7-4), 7-6 (7-5) |
| Final | Andrey Rublev | Loss | 5-7, 6-7 (4-7) |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Egor Gerasimov | Win | 3-6, 6-2, 6-2 |
| Second Round | Andy Murray | Win | 6-3, 6-4 |
| Quarterfinals | Cameron Norrie | Win | 7-5, 7-6 (7-4) |
| Semifinals | Andrey Rublev | Win | 6-7 (5-7), 6-4, 6-2 |
| Final | Stefanos Tsitsipas | Win | 6-4, 6-2 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Emil Ruusuvuori | Win | 6-4, 0-6, 3-6, 6-3, 6-4 |
| Second Round | Alejandro Davidovich Fokina | Win | 7-6 (7-4), 6-7 (4-7), 7-6 (7-5), 7-6(7-4) |
| Third Round | Daniel Evans | Win | 6-4, 6-1, 6-1 |
| Fourth Round | Marin Cilic | Win | 2-6, 7-6 (9-7), 6-2, 7-6(7-4) |
| Quarterfinals | Daniil Medvedev | Loss | 7-6 (7-4), 6-3, 6-7 (2-7), 5-7, 4-6 |
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